Scientists from Moderna have acknowledged potential toxicity risks associated with the messenger ribonucleic acid (mRNA) technology used in their COVID-19 vaccine. Published in Nature Reviews Drug Discovery, the paper highlights challenges in efficiently addressing these risks. The toxicity concerns relate to lipid nanoparticle structural components, production methods, route of administration, and proteins produced from complexed mRNAs. The paper emphasizes the need for techniques to mitigate these risks. While Moderna’s mRNA vaccine has been deemed safe and effective, potential side effects, such as heart inflammation and severe allergic reactions, are acknowledged. Some experts, like Dr. Robert Malone, suggest that the paper may downplay certain risks and caution against a limited disclosure strategy. The authors propose a multipronged approach, including advanced testing and adjustments in preclinical trials, to reduce toxicity risks associated with mRNA-based vaccines.
February 6, 2024