The Coalition for Epidemic Preparedness Innovations (CEPI), a Gates-funded organization and Jurata Thin Film, Inc. developing a needle-free mRNA vaccine delivered under the tongue.

CEPI is investing up to $1.2 million to transform Quantoom Biosciences’ mRNA-containing lipid nanoparticle (LNP) vaccine materials into a thin thermostable film. This innovation aims to address storage and transportation challenges associated with traditional vaccines, as LNPs used for mRNA delivery can pose clotting or immune system activation risks. The thin film could mitigate frozen storage requirements, potentially enhancing global vaccine distribution. If successful in clinical trials, this approach might facilitate self-administration and boost vaccine uptake in areas of hesitancy. Jurata will work on optimizing film composition and conducting preclinical studies to assess vaccine stability and delivery. Critics, including vaccine expert Dr. Robert Malone, express skepticism about the feasibility of sublingual delivery for mRNA technology. CEPI, established in 2017, collaborates with the Gates Foundation, Wellcome, and others, focusing on pandemic preparedness and vaccine development for various pathogens.